Mucus is the noun, the slimy substance itself. Mucous is the adjective that describes things related to it. Memory hook: the adjective has the extra -ous, just like nervous or jealous.
The core difference
Mucus is the slippery fluid, while mucous describes something that produces, contains or resembles it.
- mucus — the slippery fluid that lines the nose, throat and gut: A cold makes the body produce far more mucus than usual.
- mucous — relating to or resembling mucus: The mucous membrane lines the inside of your nose.
How to tell them apart
Ask yourself whether you need a thing or a description. If you are naming the substance, use mucus. If you are describing something else, such as a membrane, a coating or a gland, use mucous.
The mix-up appears most in health writing, where people write mucous for the fluid itself. Most other -ous words are adjectives too, so a noun ending in -ous should make you look twice.