In British English, practice with a C is the noun and practise with an S is the verb: you practise the piano, and you need more practice. American English uses practice for both. The C-noun, S-verb pattern is the same as advice/advise and licence/license.
The core difference
A noun and a verb in British English; one spelling in American English.
- practice (British noun) — piano practice, a medical practice.
- practise (British verb) — practise daily, a practising solicitor.
- practice (American, both).
The reliable test
Substitute advice and advise, which sound different and so are easy to hear. "I need more advice" → noun → practice. "Let me advise you" → verb → practise. The test works because both pairs follow the identical pattern.